Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7
onto replication origins in G1-phase forms the basis of replication fork establishment in S …

Abstract OriDB (http://www. oridb. org/) is a database containing collated genome-wide
mapping studies of confirmed and predicted replication origin sites. The original database …

Mutations in DNA replication initiator genes in both prokaryotes and eukaryotes lead to a
pleiotropic array of phenotypes, including defects in chromosome segregation, cytokinesis …

DNA replication initiates from defined locations called replication origins; some origins are
highly active, whereas others are dormant and rarely used. Origins also differ in their …

All chromosomes must be completely replicated prior to cell division, a requirement that
demands the activation of a sufficient number of appropriately distributed DNA replication …

Single-stranded DNA-binding proteins play many roles in nucleic acid metabolism, but their
importance during transcription remains unclear. Quantitative proteomic analysis of RNA …

The origin recognition complex (ORC) binds to the specific positions on chromosomes that
serve as DNA replication origins. Although ORC is conserved from yeast to humans, the …

The transcription factor Msn2 mediates a significant proportion of the environmental stress
response, in which a common cohort of genes changes expression in a stereotypic fashion …

FACT plays important roles in both gene transcription and DNA replication. However, how
this protein complex is targeted to these two distinct cellular processes remains largely …