[HTML][HTML] Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans

D Midkiff, A San-Miguel - Molecules, 2019 - mdpi.com
The nematode Caenorhabditis elegans is a powerful model organism that has been widely
used to study molecular biology, cell development, neurobiology, and aging. Despite their …

[HTML][HTML] Geroscience approaches to increase healthspan and slow aging

S Melov - F1000Research, 2016 - ncbi.nlm.nih.gov
For decades, researchers in the biology of aging have focused on defining mechanisms that
modulate aging by primarily studying a single metric, sometimes described as the “gold …

[HTML][HTML] NeuroChip: A Microfluidic Electrophysiological Device for Genetic and Chemical Biology Screening of Caenorhabditis elegans Adult and Larvae

C Hu, J Dillon, J Kearn, C Murray, V O'Connor… - Plos one, 2013 - journals.plos.org
Genetic and chemical biology screens of C. elegans have been of enormous benefit in
providing fundamental insight into neural function and neuroactive drugs. Recently the …

Microfluidic platform for integrated compartmentalization of single zoospores, germination and measurement of protrusive force generated by germ tubes

Y Sun, A Tayagui, A Garrill, V Nock - Lab on a Chip, 2020 - pubs.rsc.org
This paper describes the design, fabrication and characterisation of a novel monolithic lab-
on-a-chip (LOC) platform combining the trapping and germination of individual zoospores of …

[HTML][HTML] Analyzing the locomotory gaitprint of Caenorhabditis elegans on the basis of empirical mode decomposition

LC Lin, HS Chuang - PloS one, 2017 - journals.plos.org
The locomotory gait analysis of the microswimmer, Caenorhabditis elegans, is a commonly
adopted approach for strain recognition and examination of phenotypic defects. Gait is also …

[PDF][PDF] The use of lab-on-a-chip devices to measure the forces exerted by pathogenic oomycete species

H Shearer - 2018 - ir.canterbury.ac.nz
Oomycetes in the genus Phytophthora cause devastating diseases worldwide, resulting in
billions of dollars of economic damage annually. Although the control of these oomycetes is …

Microfluidic device for studying nematodes

SA Vanapalli, M Rahman - US Patent 10,668,467, 2020 - Google Patents
A microfluidic device includes a substrate, a cover layer and one or more chambers
disposed within the cover layer, the substrate or both. Each chamber has a first end, a …

Biophysical Phenotyping of Caenorhabditis Elegans in a Microfluidic Chip for Quantitative Drug Screening

S Sofela - 2020 - search.proquest.com
Drug discovery requires screening for potential synthetic or natural compounds from a vast
number of libraries and therefore, is a lengthy process. To accurately measure drug efficacy …

Microfluidic electrophysiological device for genetic and chemical biology screening of nematodes

C Hu - 2013 - eprints.soton.ac.uk
Genetic and chemical biology screens of C. elegans have been of enormous benefit in
providing fundamental insight into neural function and neuroactive drugs. Recently the …