Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer's disease

HM Ragab, M Teleb, HR Haidar, N Gouda - Bioorganic chemistry, 2019 - Elsevier
In search of potent acetyl cholinesterase inhibitors with low hepatotoxicity for the treatment of
Alzheimer's disease, introduction of a chloro substitution to tacrine and some of its analogs …

Synthesis and biological evaluation of some tacrine analogs: study of the effect of the chloro substituent on the acetylcholinesterase inhibitory activity

HM Ragab, HMA Ashour, A Galal, AI Ghoneim… - Monatshefte für Chemie …, 2016 - Springer
New tetrahydroquinoline derivatives were synthesized, characterized, and evaluated for
their in vitro and in vivo acetylcholinesterase inhibitory activity as well as hepatotoxicity …

[PDF][PDF] Studies on heterocyclic compounds of medicinal interest

DK Dodiya - 2010 - core.ac.uk
The pyridine skeleton is of great importance to chemists as well as to biologists as it is found
in a large variety of naturally occurring compounds and also in clinically useful molecules …