Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of
EGFR signaling. However, EGFR endocytosis mechanisms are poorly understood, which …

Cockayne Syndrome (CS) is a rare neurodegenerative disease characterized by short
stature, accelerated aging and short lifespan. Mutations in two human genes, ERCC8/CSA …

Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because
aberrant EGFR activity may cause cell transformation. Receptor-associated late transducer …

Regulated endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type
glutamate receptors (AMPARs) is critical for synaptic plasticity. However, the specific …

Enlarged early endosomes in the neurons of young Down syndrome (DS) and pre-
Alzheimer's disease (AD) brains suggest that a disturbance in endocytosis is one of the …

Intersectin-short (intersectin-s) is a multimodule scaffolding protein functioning in constitutive
and regulated forms of endocytosis in non-neuronal cells and in synaptic vesicle (SV) …

Adaptor/scaffold proteins serve as platforms for the assembly of multiprotein complexes and
regulate the efficiency and specificity of signalling cascades. Intersectins (ITSNs) are an …

While endocytosis attenuates signals from plasma membrane receptors, recent studies
suggest that endocytosis also serves as a platform for the compartmentalized activation of …