Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because
of dMMR-induced neoantigens and activation of the cGAS-STING pathway. While …

Dynamic chromatin behavior plays a critical role in various genome functions. However, it
remains unclear how chromatin behavior changes during interphase, where the nucleus …

Abstract Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to
collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts …

RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …

DNA-dependent protein kinase (DNA-PK) plays a critical role in non-homologous end
joining (NHEJ), the predominant pathway that repairs DNA double-strand breaks (DSB) in …

Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of
DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being …

Radiotherapy is one of the most effective and frequently used treatments for a wide range of
cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment …

DNA double-strand breaks drive genomic instability. However, it remains unknown how
these processes may affect the biomechanical properties of the nucleus and what role …