[HTML][HTML] Molecular mechanisms of tumor resistance to radiotherapy
Y Wu, Y Song, R Wang, T Wang - Molecular Cancer, 2023 - Springer
Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …
considered the standard of care for most solid tumors, including lung, breast, esophageal …
[HTML][HTML] DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …
tumors. However, the radioresistance of cancer cells is still a major limitation for …
[HTML][HTML] MLH1 deficiency-triggered DNA hyperexcision by exonuclease 1 activates the cGAS-STING pathway
Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because
of dMMR-induced neoantigens and activation of the cGAS-STING pathway. While …
of dMMR-induced neoantigens and activation of the cGAS-STING pathway. While …
Single-nucleosome imaging reveals steady-state motion of interphase chromatin in living human cells
Dynamic chromatin behavior plays a critical role in various genome functions. However, it
remains unclear how chromatin behavior changes during interphase, where the nucleus …
remains unclear how chromatin behavior changes during interphase, where the nucleus …
[HTML][HTML] RNAPII-dependent ATM signaling at collisions with replication forks
Abstract Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to
collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts …
collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts …
[HTML][HTML] Human RecQ helicases in DNA double-strand break repair
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …
animals. These helicases play important roles in multiple cellular functions, including DNA …
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
PSE Head, P Kapoor-Vazirani… - Nucleic acids …, 2023 - academic.oup.com
DNA-dependent protein kinase (DNA-PK) plays a critical role in non-homologous end
joining (NHEJ), the predominant pathway that repairs DNA double-strand breaks (DSB) in …
joining (NHEJ), the predominant pathway that repairs DNA double-strand breaks (DSB) in …
Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010–present)
S Hu, Z Hui, F Lirussi, C Garrido, XY Ye… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of
DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being …
DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being …
[HTML][HTML] Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy
CML Chan Wah Hak, A Rullan, EC Patin… - Frontiers in …, 2022 - frontiersin.org
Radiotherapy is one of the most effective and frequently used treatments for a wide range of
cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment …
cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment …
DNA damage alters nuclear mechanics through chromatin reorganization
Á Dos Santos, AW Cook, RE Gough… - Nucleic acids …, 2021 - academic.oup.com
DNA double-strand breaks drive genomic instability. However, it remains unknown how
these processes may affect the biomechanical properties of the nucleus and what role …
these processes may affect the biomechanical properties of the nucleus and what role …