血管内皮细胞和内皮细胞释放的活性因子是调控血管舒张功能的重要因素. 糖尿病是慢性心血管
疾病的高危因素之一. 目前认为高糖和糖尿病引起的内皮细胞功能障碍是造成血管功能改变 …

The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic
and preventative strategies to attenuate complications of this debilitating disease. Diabetic …

Background. The mitochondrial dynamics and mitochondrial biogenesis are essential for
maintaining the bioenergy function of mitochondria in diabetic cardiomyopathy (DCM) …

Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

Chronic, low-grade systemic inflammation and impaired microvascular function are critical
hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major …

Cardiometabolic diseases (CMDs) are metabolic diseases (eg, obesity, diabetes,
atherosclerosis, rare genetic metabolic diseases, etc.) associated with cardiac pathologies …

The heart is able to metabolize any substrate, depending on its availability, to satisfy its
energy requirements. Under normal physiological conditions, about 95% of ATP is produced …

In recent years, the incidence of diabetes has been increasing rapidly, which seriously
endangers human health. Diabetic cardiomyopathy, an important cardiovascular …

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach,
given that mitochondrial defects are thought to contribute to many prevalent diseases and …

Iron overload increases the production of harmful reactive oxygen species in the Fenton
reaction, which causes oxidative stress in the body and lipid peroxidation in the cell …