Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Abstract Mammalian Staufen (Stau) 1 is an RNA binding protein that is thought to function in
mRNA transport and translational control. Nonsense-mediated mRNA decay (NMD) …

RNA binding proteins may be important mediators of the activity-dependent transport of
mRNAs to dendritic spines of activated synapses. We used fluorescence microscopy and …

In neurons, the proteins derived from mRNAs localized in dendrites have been implicated in
synaptic plasticity. The cytoplasmic polyadenylation element (CPE), a cis element in the 3 …

The regulated translation of localized mRNAs in neurons provides a mechanism for spatially
restricting gene expression in a synapse-specific manner. To identify the population of …

Eukaryotic cells express a large variety of ribonucleic acid-(RNA)-binding proteins (RBPs)
with diverse affinity and specificity towards target RNAs that play a crucial role in almost …

UPF1 functions in both Staufen 1 (STAU1)-mediated mRNA decay (SMD) and nonsense-
mediated mRNA decay (NMD), which we show here are competitive pathways. STAU1-and …

RNAs are present in dendrites and may be used for local protein synthesis in response to
synaptic activity. To begin to understand dendritic RNA targeting, we cloned a rat homolog of …

In eukaryotes, the entwined pathways of RNA transport and local translational regulation are
key determinants in the spatio-temporal articulation of gene expression. One of the main …