Membrane transporters in drug development and as determinants of precision medicine
A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …
recognized. Since the initial publication from the International Transporter Consortium …
Effect of cimetidine on metformin pharmacokinetics and endogenous metabolite levels in rats
Tubular secretion is a primary mechanism along with glomerular filtration for renal
elimination of drugs and toxicants into urine. Organic cation transporters (OCTs) and …
elimination of drugs and toxicants into urine. Organic cation transporters (OCTs) and …