Membrane transporters in drug development and as determinants of precision medicine

A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Effect of cimetidine on metformin pharmacokinetics and endogenous metabolite levels in rats

AS Ailabouni, VS Mettu, A Thakur, DK Singh… - Drug Metabolism and …, 2024 - ASPET
Tubular secretion is a primary mechanism along with glomerular filtration for renal
elimination of drugs and toxicants into urine. Organic cation transporters (OCTs) and …