Physical activity in the prevention of human diseases: role of epigenetic modifications

E Grazioli, I Dimauro, N Mercatelli, G Wang, Y Pitsiladis… - BMC genomics, 2017 - Springer
Epigenetic modification refers to heritable changes in gene function that cannot be
explained by alterations in the DNA sequence. The current literature clearly demonstrates …

The role of cytokines in the pathogenesis of schizophrenia

B Dawidowski, A Górniak, P Podwalski… - Journal of Clinical …, 2021 - mdpi.com
Schizophrenia is a chronic mental illness of unknown etiology. A growing and compelling
body of evidence implicates immunologic dysfunction as the key element in its …

Epigenetics of schizophrenia

A Srivastava, O Dada, J Qian, N Al-Chalabi… - Psychiatry …, 2021 - Elsevier
Schizophrenia (SCZ) is a chronic psychotic disorder that contributes significantly to
disability, affecting behavior, thought, and cognition. It has long been known that there is a …

Epigenetic modifications as outcomes of exercise interventions related to specific metabolic alterations: a systematic review

E Barrón-Cabrera, O Ramos-Lopez… - Lifestyle …, 2019 - karger.com
Background: Chronic diseases arise as a consequence of an unhealthy lifestyle primarily
characterized by physical inactivity and unbalanced diets. Regular physical activity can …

Role of physical exercise in the regulation of epigenetic mechanisms in inflammation, cancer, neurodegenerative diseases, and aging process

M Ferioli, G Zauli, P Maiorano, D Milani… - Journal of cellular …, 2019 - Wiley Online Library
The genetic heritage for decades has been considered to respond only to gene promoters or
suppressors, with specific roles for oncogenes or tumor‐suppressor genes. Epigenetics is …

A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training

H Lee, K Kim, B Kim, J Shin, S Rajan… - The Journal of …, 2018 - Wiley Online Library
Key points Referring to the muscle memory theory, previously trained muscles acquire
strength and volume much faster than naive muscles. Using extreme experimental models …

Effects of physical exercise on autophagy and apoptosis in aged brain: Human and animal studies

DZ Andreotti, JN Silva, AM Matumoto… - Frontiers in …, 2020 - frontiersin.org
The aging process is characterized by a series of molecular and cellular changes over the
years that could culminate in the deterioration of physiological parameters important to …

Effects of grape juice consumption on oxidative stress and inflammation in male volleyball players: A randomized, double-blind, placebo-controlled clinical trial

NC Martins, GP Dorneles, AS Blembeel… - … therapies in medicine, 2020 - Elsevier
Introduction Some foods are also demonstrated benefits, such as anti-inflammatory,
antioxidant, and ergogenic activity, similar to that of sports supplements. Grape juice has …

Advances and current challenges associated with the use of human induced pluripotent stem cells in modeling neurodegenerative disease

BJ Berry, AST Smith, JE Young, DL Mack - Cells Tissues Organs, 2019 - karger.com
One of the most profound advances in the last decade of biomedical research has been the
development of human induced pluripotent stem cell (hiPSC) models for identification of …

Acute strenuous exercise induces an imbalance on histone H4 acetylation/histone deacetylase 2 and increases the proinflammatory profile of PBMC of obese …

GP Dorneles, MCR Boeira, LL Schipper… - Oxidative Medicine …, 2017 - Wiley Online Library
This study evaluated the response of global histone H4 acetylation (H4ac), histone
deacetylase 2 (HDAC2) activity, as well as the production of proinflammatory cytokines and …