Oral relugolix for androgen-deprivation therapy in advanced prostate cancer

ND Shore, F Saad, MS Cookson… - … England Journal of …, 2020 - Mass Medical Soc
Background Injectable luteinizing hormone–releasing hormone agonists (eg, leuprolide) are
the standard agents for achieving androgen deprivation for prostate cancer despite the initial …

Cardiovascular risks and toxicity-The Achilles heel of androgen deprivation therapy in prostate cancer patients

S Muniyan, L Xi, K Datta, A Das, BA Teply… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Androgen deprivation therapy (ADT) is the primary systemic therapy for treating locally
advanced or metastatic prostate cancer (PCa). Despite its positive effect on PCa patient …

Stem cells as target for prostate cancer therapy: opportunities and challenges

C Escudero-Lourdes, I Alvarado-Morales… - Stem cell reviews and …, 2022 - Springer
Cancer stem cells (CSCs) and cells in a cancer stem cell-like (CSCL) state have proven to
be responsible for tumor initiation, growth, and relapse in Prostate Cancer (PCa) and other …

Metabolic consequences of gonadotropin‐releasing hormone agonists vs orchiectomy: a randomized clinical study

PB Østergren, C Kistorp, M Fode… - BJU …, 2019 - Wiley Online Library
Objectives To compare the metabolic changes between men with advanced prostate cancer
commenced on a gonadotropin‐releasing hormone (Gn RH) agonist and those treated with …

Follicle-stimulating hormone provokes macrophages to secrete IL-1β contributing to atherosclerosis progression

J Han, Y Song, W Yao, J Zhou, Y Du… - The Journal of …, 2023 - journals.aai.org
Abnormally high follicle-stimulating hormone (FSH) has been reported to associate with
cardiovascular diseases in prostate cancer patients with specific androgen deprivation …

Follicle-stimulating hormone exacerbates cardiovascular disease in the presence of low or castrate testosterone levels

WCM Duivenvoorden, D Margel… - Basic to Translational …, 2024 - jacc.org
Low testosterone (T), common in aging men, associates with cardiovascular disease. We
investigated whether follicle-stimulating hormone (FSH), which is affected by T, modulates …

Cardio-oncology in advanced prostate cancer

K Chen, TH Wong, YG Tan, KJ Tay… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Treatment intensification with androgen deprivation therapy (ADT) and androgen receptor
pathway inhibitors (ARPi) have led to improved survival in advanced prostate cancer …

Surgical versus medical castration for metastatic prostate cancer: use and overall survival in a national cohort

AB Weiner, JE Cohen, JO DeLancey… - The Journal of …, 2020 - auajournals.org
Purpose: Surgical castration for metastatic prostate cancer is used less frequently than
medical castration yet costs less, requires less followup and may be associated with fewer …

Is androgen deprivation therapy for prostate cancer associated with cardiovascular disease? A meta‐analysis and systematic review

Z Liang, J Zhu, L Chen, Y Xu, Y Yang, R Hu… - …, 2020 - Wiley Online Library
Background Androgen deprivation therapy (ADT) is widely being applied in men who
suffered from prostate cancer. Whether androgen deprivation therapy (ADT) is associated …

Cardiovascular effects of androgen deprivation therapy in prostate cancer

M Agarwal, T Canan, G Glover, N Thareja… - Current oncology …, 2019 - Springer
Abstract Purpose of the Review This review paper is a comprehensive look at the
cardiovascular disease (CVD) risk that is associated with the use of androgen deprivation …