Soft tissue tumors are a relatively rare and diagnostically challenging group of neoplasms
that can have varying lines of differentiation. Accurate diagnosis is important for appropriate …

The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and
Bone was published in early 2020. The revisions reflect a consensus among an …

Bone tumors are a rare and heterogeneous group of neoplasms that occur in the bone. The
diversity and considerable morphologic overlap of bone tumors with other mesenchymal …

CIC-DUX4 gene fusion, resulting from either at (4; 19) or t (10; 19) translocation, is the most
common genetic abnormality detected in EWSR1-negative small blue round cell tumors …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

CIC-fused sarcomas represent an emerging family of tumors, for long connected to the
Ewing family group of tumors, but underlined by distinct CIC fusions with different partners …

A distinct subset of round cell sarcomas harbors capicua transcriptional repressor (CIC)
rearrangement. Diagnosing these sarcomas can be difficult owing to their resemblance to …

Subsets of primitive round-cell sarcomas remain difficult to diagnose and classify. Among
these is a rare round-cell sarcoma that harbors a CIC gene rearrangement known as CIC …

Abstract CIC-DUX4 sarcoma (CDS) or CIC-rearranged sarcoma is a subcategory of small
round cell sarcoma resembling the morphological phenotypes of Ewing sarcoma (ES) …

Capicua transcriptional repressor (CIC)-rearranged sarcoma represents a distinct pathologic
entity and constitutes the second most prevalent category of undifferentiated round cell …