[HTML][HTML] Identification and validation of neurotrophic factor-related gene signatures in glioblastoma and Parkinson's disease

S Zhao, H Chi, Q Yang, S Chen, C Wu, G Lai… - Frontiers in …, 2023 - frontiersin.org
Background Glioblastoma multiforme (GBM) is the most common cancer of the central
nervous system, while Parkinson's disease (PD) is a degenerative neurological condition …

Potential for stem cells therapy in Alzheimer's disease: do neurotrophic factors play critical role?

P Bali, DK Lahiri, A Banik, B Nehru… - Current Alzheimer …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several
decades of research in AD, there is no standard disease-modifying therapy available and …

[HTML][HTML] Alternative targets to fight Alzheimer's disease: focus on astrocytes

M Valenza, R Facchinetti, G Menegoni, L Steardo… - Biomolecules, 2021 - mdpi.com
The available treatments for patients affected by Alzheimer's disease (AD) are not curative.
Numerous clinical trials have failed during the past decades. Therefore, scientists need to …

Extracellular Vesicles Released from Neprilysin Gene‐Modified Human Umbilical Cord‐Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an …

HJ Jeong, OJ Kim, SH Oh, S Lee… - Stem cells …, 2021 - Wiley Online Library
Alzheimer's disease (AD) animal studies have reported that mesenchymal stem cells
(MSCs) have therapeutic effects; however, clinical trial results are controversial. Neprilysin …

[HTML][HTML] Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer's disease

XM Zhang, YJ Ouyang, BQ Yu, W Li… - Neural regeneration …, 2021 - journals.lww.com
Dental pulp stem cells are dental pulp-derived mesenchymal stem cells that originate from
the neural crest. They exhibit greater potential for the treatment of nervous system diseases …

The effects of betulinic acid on neurobehavioral activity, electrophysiology and histological changes in an animal model of the Alzheimer's disease

SP Navabi, A Sarkaki, E Mansouri, M Badavi… - Behavioural brain …, 2018 - Elsevier
Alzheimer's disease (AD) is a common disorder characterized by aggregation and
conversion of amyloid beta (Aβ) monomers to fibrils. Betulinic acid (BA) strongly accelerated …

Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer's disease: A systematic review and meta‐analysis

M Ge, Y Zhang, Q Hao, Y Zhao, B Dong - Brain and behavior, 2018 - Wiley Online Library
Background Alzheimer's disease (AD) is a globally prevalent neurodegenerative disease,
clinically characterized by progressive memory loss and gradual impairment of cognitive …

Lindera glauca Blume ameliorates amyloid-β1-42-induced memory impairment in mice with neuroprotection and activation of the CREB-BDNF pathway

Y Kim, SH Cho - Neurochemistry International, 2021 - Elsevier
Background Alzheimer's disease (AD) is a neurodegenerative disorder presenting cognitive
decline accompanied by deposits of amyloid-β (Aβ) and tau hyperphosphorylation. Without …

Neurotrophic factors mediated activation of astrocytes ameliorate memory loss by amyloid clearance after transplantation of lineage negative stem cells

P Bali, A Banik, B Nehru, A Anand - Molecular Neurobiology, 2019 - Springer
Alzheimer's disease (AD) is one of the untreatable neurodegenerative disorders with
associated societal burden. Current therapies only provide symptomatic relief without …

[HTML][HTML] Short-lived human umbilical cord-blood-derived neural stem cells influence the endogenous secretome and increase the number of endogenous neural …

A Jablonska, K Drela, L Wojcik-Stanaszek… - Molecular …, 2016 - Springer
Stroke is the leading cause of severe disability, and lacunar stroke is related to cognitive
decline and hemiparesis. There is no effective treatment for the majority of patients with …