Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
Next-generation influenza vaccines: opportunities and challenges
CJ Wei, MC Crank, J Shiver, BS Graham… - Nature reviews Drug …, 2020 - nature.com
Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains.
Developing improved vaccines that elicit broader immunity remains a public health priority …
Developing improved vaccines that elicit broader immunity remains a public health priority …
Biomedical applications of DNA‐based hydrogels
J Gačanin, CV Synatschke… - Advanced Functional …, 2020 - Wiley Online Library
Nucleic acids are gaining significant attention as versatile building blocks for the next
generation of soft materials. Due to significant advances in the chemical synthesis and …
generation of soft materials. Due to significant advances in the chemical synthesis and …
Immune sensing mechanisms that discriminate self from altered self and foreign nucleic acids
E Bartok, G Hartmann - Immunity, 2020 - cell.com
All lifeforms have developed highly sophisticated systems equipped to detect altered self
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …
Treating disease at the RNA level with oligonucleotides
AA Levin - New England Journal of Medicine, 2019 - Mass Medical Soc
Oligonucleotides in Drug Development As research on the structure and function of RNAs
has rapidly expanded, so too has the number of oligonucleotide drugs in clinical …
has rapidly expanded, so too has the number of oligonucleotide drugs in clinical …
Comparative safety of vaccine adjuvants: a summary of current evidence and future needs
N Petrovsky - Drug safety, 2015 - Springer
Use of highly pure antigens to improve vaccine safety has led to reduced vaccine
immunogenicity and efficacy. This has led to the need to use adjuvants to improve vaccine …
immunogenicity and efficacy. This has led to the need to use adjuvants to improve vaccine …
CpG DNA as a vaccine adjuvant
C Bode, G Zhao, F Steinhagen, T Kinjo… - Expert review of …, 2011 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
Nucleic acid immunity
G Hartmann - Advances in immunology, 2017 - Elsevier
Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …
Therapeutic potential of Toll-like receptor 9 activation
AM Krieg - Nature reviews Drug discovery, 2006 - nature.com
In the decade since the discovery that mouse B cells respond to certain unmethylated CpG
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
Toll-like receptor 9 agonists in cancer
L Karapetyan, JJ Luke, D Davar - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly
located intracellularly in immune cells, including dendritic cells, macrophages, natural killer …
located intracellularly in immune cells, including dendritic cells, macrophages, natural killer …