Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …

Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy
environment within the cell. However, when natural proteostasis mechanisms are …

Natural product compounds have recently attracted significant attention from the scientific
community for their potent effects against inflammation-driven diseases, including cancer. A …

The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …

Tumors can be divided into 'hot'(T cell inflamed) or 'cold'(T cell noninflamed) according to the
presence of immune cells. In this review, we discuss variables that influence T cell migration …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

A systematic characterization of the genetic alterations driving ALCLs has not been
performed. By integrating massive sequencing strategies, we provide a comprehensive …

Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various
types of cancer, including head and neck squamous cell carcinoma (HNSCC). In this study …

Thymoquinone is an active ingredient isolated from Nigella sativa and has been
investigated for its anti-oxidant, anti-inflammatory and anticancer activities in both in vitro …

The use of mesenchymal stem cells (MSC) for tissue repair has garnered much interest and
has been evaluated in several disease settings. Recent evidence indicates that the …