HCC is not a major killer among malignant diseases in Western countries, and until recently
few Western hepatologists were interested in this cancer. After the demonstration of an …

The accumulation of genetic damage in the forms of activated proto-oncogenes and
inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a …

Transgenic mice that overproduce the hepatitis B virus large envelope polypeptide and
accumulate toxic quantities of hepatitis B surface antigen (HBsAg) within the hepatocyte …

There is little information regarding the molecular mechanisms of hepatocarcinogenesis. We
studied the p53 gene at the DNA, RNA, and protein level in seven human hepatocellular …

Both basic and clinical aspects are stressed, including the biochemical, anatomic,
physiologic, and pathologic. Emphasis is on the diagnosis and treatment of liver disease …

The validity of mouse liver tumor end points in assessing the potential hazards of chemical
exposure to humans is a controversial but important issue, since liver neoplasia in mice is …

Two hepatocellular carcinomas, induced in woodchucks chronically infected with
woodchuck hepatitis virus, were characterized for viral integration near c-myc and …

The transcriptional regulatory activity of the human hepatitis B virus (HBV) X‐gene product
was investigated. We demonstrate a new property for the HBV X‐gene, the strong …

The hst gene was originally identified as a transforming gene in DNAs from human stomach
cancers and from a noncancerous portion of stomach mucosa by DNA-mediated transfection …

The role of cellular oncogenes in the development of epithelial tumors of the human female
reproductive tract has not previously been extensively studied. DNAs isolated from ten …