Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

Brain metastasis, the most lethal form of melanoma and carcinoma, is the consequence of
favorable interactions between the invading cancer cells and the brain cells. Peroxisome …

Acral lentiginous melanoma is a histological subtype of cutaneous melanoma that occurs in
the glabrous skin of the palms, soles and the nail unit. Although in some countries …

Telomerase is an attractive target for anti-tumor therapy as it is almost universally expressed
in cancer cells. Here, we show that treatment with a telomere-targeting drug, 6-thio-2 …

Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to
chromosome ends and is upregulated in most human cancers to enable limitless …

Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping
from cell senescence. As the key component of telomerase, telomerase reverse …

Standard and targeted cancer therapies for late-stage cancer patients almost universally fail
due to tumor heterogeneity/plasticity and intrinsic or acquired drug resistance. We used the …

PURPOSE Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the
contribution of telomerase and alternative lengthening of telomeres (ALT) to clinical …

Engaging a telomere maintenance mechanism during DNA replication is essential for
almost all advanced cancers. The conversion from normal and premalignant somatic cells to …