The expression of gamma-glutamyl transpeptidase (GGT) is essential to maintaining
cysteine levels in the body. GGT is a cell surface enzyme that hydrolyzes the gamma …

Having long been regarded as just a member in the cellular antioxidant systems, as well as
a clinical biomarker of hepatobiliary diseases and alcohol abuse, gamma …

Oxidative stress is a central part of innate immune-induced neurodegeneration. However,
the transcriptomic landscape of central nervous system (CNS) innate immune cells …

Background & Aims EDP-305 is an oral farnesoid X receptor (FXR) agonist under
development for treating nonalcoholic steatohepatitis (NASH). The efficacy, safety, and …

Gamma-glutamyl transpeptidase (GGT) is an enzyme located on the outer membrane of the
cells where it regulates the metabolism of glutathione (GSH), the most abundant intracellular …

Background & Aims The LIVIFY trial investigated the safety, tolerability, and efficacy of
vonafexor, a second-generation, non-bile acid farnesoid X receptor agonist in patients with …

Atherosclerosis is a lipoprotein‐driven disease, and there is no effective therapy to reverse
atherosclerosis or existing plaques. Therefore, it is urgently necessary to create a …

Breast cancer is the malignant neoplasia with the highest incidence in women worldwide.
Chronic oxidative stress and inflammation have been indicated as major mediators during …

γ-Glutamyltranspeptidase (GGT) plays critical roles in regulating various physiological/
pathophysiological processes including the intracellular redox homeostasis. However, an …

Idiopathic pulmonary fibrosis (IPF), whose early diagnosis and effective treatment still
remain the focus of clinical studies, is a chronic, irreversible and finally fatal pulmonary …