[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

M Fedele, R Piersanti, F Regazzoni, M Salvador… - Computer Methods in …, 2023 - Elsevier
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

R Piersanti, F Regazzoni, M Salvador, AF Corno… - Computer Methods in …, 2022 - Elsevier
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …

lifex-fiber: an open tool for myofibers generation in cardiac computational models

PC Africa, R Piersanti, M Fedele, L Dede'… - BMC …, 2023 - Springer
Background Modeling the whole cardiac function involves the solution of several complex
multi-physics and multi-scale models that are highly computationally demanding, which call …

Post-bifurcation of inflated fibrous cylindrical membranes under different fiber configurations

H Topol, H Asghari, M Stoffel, B Markert… - European Journal of …, 2023 - Elsevier
We consider a cylindrical membrane that consists of an isotropic ground substance and
fibers symmetrically arranged in two helically distributed families which are mechanically …

[HTML][HTML] An updated Lagrangian constrained mixture model of pathological cardiac growth and remodelling

D Guan, X Zhuan, X Luo, H Gao - Acta Biomaterialia, 2023 - Elsevier
Progressive left ventricular (LV) growth and remodelling (G&R) is often induced by volume
and pressure overload, characterized by structural and functional adaptation through …

Fourier transform-based method for quantifying the three-dimensional orientation distribution of fibrous units

R Alberini, A Spagnoli, MJ Sadeghinia, B Skallerud… - Scientific Reports, 2024 - nature.com
Several materials and tissues are characterized by a microstructure composed of fibrous
units embedded in a ground matrix. In this paper, a novel three-dimensional (3D) Fourier …

[HTML][HTML] A new active contraction model for the myocardium using a modified hill model

D Guan, H Gao, L Cai, X Luo - Computers in Biology and Medicine, 2022 - Elsevier
This study develops a new hybrid active contraction model for myocardial dynamics
abstracted from sarcomere by combining the phenomenologically active-stress based Hill …

[HTML][HTML] A software benchmark for cardiac elastodynamics

R Aróstica, D Nolte, A Brown, A Gebauer… - Computer Methods in …, 2025 - Elsevier
In cardiovascular mechanics, reaching consensus in simulation results within a
physiologically relevant range of parameters is essential for reproducibility purposes …

[HTML][HTML] Advanced statistical inference of myocardial stiffness: A time series Gaussian process approach of emulating cardiac mechanics for real-time clinical decision …

Y Ge, D Husmeier, A Rabbani, H Gao - Computers in Biology and Medicine, 2025 - Elsevier
Cardiac mechanics modelling promises to revolutionize personalized health care; however,
inferring patient-specific biophysical parameters, which are critical for understanding …

[HTML][HTML] Using LDDMM and a kinematic cardiac growth model to quantify growth and remodelling in rat hearts under PAH

D Guan, L Tian, W Li, H Gao - Computers in Biology and Medicine, 2024 - Elsevier
Pulmonary arterial hypertension (PAH) is a rapidly progressive and fatal disease, with right
ventricular failure being the primary cause of death in patients with PAH. This study aims to …