Alzheimer's disease (AD) is characterized by progressive accumulation of misfolded
proteins, which form senile plaques and neurofibrillary tangles, and the release of …

Despite its key role in the molecular pathology of Alzheimer's disease (AD), the
physiological function of amyloid precursor protein (APP) is unknown. Increasing evidence …

With the long-standing amyloid cascade hypothesis (ACH) largely discredited, there is an
acute need for a new all-encompassing interpretation of Alzheimer's disease (AD). Whereas …

Although the long-standing Amyloid Cascade Hypothesis (ACH) has been largely
discredited, its main attribute, the centrality of amyloid-beta (Aβ) in Alzheimer's disease (AD) …

Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of
millions of people affected worldwide. The pathogenesis is still poorly understood and …

The two most abundant molecules on synaptic vesicles (SVs) are synaptophysin and
synaptobrevin‐II (sybII). SybII is essential for SV fusion, whereas synaptophysin is proposed …

Amyloid precursor protein (APP) is processed along the amyloidogenic pathway by the β-
secretase, BACE1, generating β-amyloid (Aβ), or along the nonamyloidogenic pathway by α …

For at least two reasons, the current transgenic animal models of Alzheimer's disease (AD)
appear to be patently inadequate. They may be useful in many respects, the AD models; …

Abstract Pyk2 is a Ca 2+-activated non-receptor tyrosine kinase enriched in forebrain
neurons and involved in synaptic regulation. Human genetic studies associated PTK2B, the …

Munc18-interacting proteins (Mints) are multidomain adaptors that regulate neuronal
membrane trafficking, signaling, and neurotransmission. Mint1 and Mint2 are highly …