Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

Bones provide mechanical and protective function, while also serving as housing for marrow
and a site for regulation of calcium ion homeostasis. The properties of bones do not remain …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Osteoporosis is a growing major public health problem with impact that crosses medical,
social, and economic lines. These guidelines have been developed by the American …

MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of
gene regulation that coordinates a broad spectrum of biological processes. Bone …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Osteoporosis is among the most common and costly diseases and is increasing in
prevalence owing to the ageing of our global population. Clinically defined largely through …

TwinsUK is a nation-wide registry of volunteer twins in the United Kingdom, with about
12,000 registered twins (83% female, equal number of monozygotic and dizygotic twins …

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and
bone mineral density (BMD) by performing two separate genome-wide association study …

The ratio of false-positive to false-negative findings (FP: FN ratio) is an informative metric
that warrants further evaluation. The FP: FN ratio varies greatly across different …