[HTML][HTML] Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases

T Pant, N Uche, M Juric, J Zielonka, X Bai - Redox Biology, 2024 - Elsevier
Inflammatory diseases present a serious health challenge due to their widespread
prevalence and the severe impact on patients' lives. In the quest to alleviate the burden of …

The pharmacogenetics of natural products: A pharmacokinetic and pharmacodynamic perspective

T Rao, Z Tan, J Peng, Y Guo, Y Chen, H Zhou… - Pharmacological …, 2019 - Elsevier
Natural products have represented attractive alternatives for disease prevention and
treatment over the course of human history and have contributed to the development of …

Resveratrol: Change of SIRT 1 and AMPK signaling pattern during the aging process

CA Caldeira, MA Santos, GR Araújo, RC Lara… - Experimental …, 2021 - Elsevier
One of the causes for aging is free radical damage. Resveratrol (RSV), a polyphenolic
compound has been shown to act as an antioxidant and anti-inflammatory. The objective …

A genetic score of predisposition to low-grade inflammation associated with obesity may contribute to discern population at risk for metabolic syndrome

S Galmés, M Cifre, A Palou, P Oliver, F Serra - Nutrients, 2019 - mdpi.com
Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo
system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and …

Pomegranate seed oil nanoemulsions with selective antiglioma activity: optimization and evaluation of cytotoxicity, genotoxicity and oxidative effects on mononuclear …

L Mota Ferreira, M Gehrcke, V Ferrari Cervi… - Pharmaceutical …, 2016 - Taylor & Francis
Context: Glioma is a malignant brain tumor with rapid proliferation, infiltrative growth, poor
prognosis and it is chemoresistent. Pomegranate seed oil (PSO) has antioxidant, anti …

A genomics perspective of personalized prevention and management of obesity

KK Gkouskou, MG Grammatikopoulou, E Lazou… - Human Genomics, 2024 - Springer
This review discusses the landscape of personalized prevention and management of
obesity from a nutrigenetics perspective. Focusing on macronutrient tailoring, we discuss the …

[HTML][HTML] Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells

CR Rampelotto, VG Pereira, L da Silva Silveira… - Toxicology in Vitro, 2022 - Elsevier
Ferulic acid (FA) is a phenolic compound that has antioxidant, anti-inflammatory and
anticarcinogenic properties besides presenting cytoprotective activity. It has limited oral …

Ziprasidone, a second-generation antipsychotic drug, triggers a macrophage inflammatory response in vitro

T Duarte, F Barbisan, PAS do Prado-Lima, VF Azzolin… - Cytokine, 2018 - Elsevier
Antipsychotic drugs are used to treat schizophrenia and other psychiatric disorders.
However, most of these drugs present side effects causing obesity and other serious …

The In Vitro Influence of a Genetic Superoxide-Hydrogen Peroxide Imbalance on Immunosenescence

F Barbisan, VF Azzolin, EE Ribeiro… - Rejuvenation …, 2017 - liebertpub.com
As superoxide is a key molecule of inflammatory activation, superoxide-hydrogen peroxide
(S-HP) imbalance genetically caused could alter immunosenescence patterns. To test this …

[HTML][HTML] Brazil nut improves the oxidative metabolism of superoxide-hydrogen peroxide chemically-imbalanced human fibroblasts in a nutrigenomic manner

KL Schott, CE Assmann, CF Teixeira… - Food and Chemical …, 2018 - Elsevier
There are some genes associated to the risk of chronic diseases that present potential
nutrigenetic response, such as the human manganese-dependent superoxide dismutase …