Lung cancer diagnosis is a challenge since it is also one of the most frequently diagnosed
cancers. Diagnostic challenges are deeply related to the development of personalized …

The fibroblast growth factor receptors (FGFR) play essential roles both during development
and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that …

Patients with non-small cell lung cancer (NSCLC) that harbors epidermal growth factor
receptor (EGFR) mutations initially respond to EGFR-tyrosine kinase inhibitors (TKI) but …

Background Some tyrosine kinase receptors (RTKs) play critical roles in gastric cancer
progression. Not only trastuzumab, but also several other agents targeting RTKs are being …

PRMT5 (protein arginine methyltransferase 5) is an enzyme that catalyses transfer of methyl
groups from S-adenosyl methionine to the arginine residues of histones or non-histone …

Motivation Identification of novel therapeutic effects for existing US Food and Drug
Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to …

Abstract Fibroblast growth factor 7 (FGF7) is a mesenchyme-specific heparin-binding growth
factor that binds FGF receptor 2 (FGFR2) to regulate numerous cellular and physiological …

Despite improvement in our understanding of long noncoding RNAs (lncRNAs) role in
cancer, efforts to find clinically relevant cancer-associated lncRNAs are still lacking. Here …

Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and
is associated with decreased or absent expression of the transcription factor NK2 homeobox …

Purpose: Enhancer of zeste homolog 2 (EZH2) promotes carcinogenesis by epigenetically
silencing tumor suppressor genes. We studied EZH2 expression by immunohistochemistry …