The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

The interplay between the tumor cells and their microenvironments is as inseparable as the
relationship between “seeds” and “soil.” The tumor microenvironments (TMEs) exacerbate …

Abstract γ-Amino acids and peptides analogues are common constituents of building blocks
for numerous biologically active molecules, pharmaceuticals, and natural products. In …

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases,
showcasing a wide range of applications. Their unique advantages, such as rich source …

Polymer-drug conjugates (PDCs) have emerged as an advanced strategy in the drug
delivery. The conjugation of therapeutic or diagnostic agents to polymers, such as …

Androgen deprivation therapy is administered to suppress the growth of prostate cancer
(PCa). However, some cells continue to proliferate independent of hormones, leading to the …

Nanomedicines have significantly advanced the development of diagnostic and therapeutic
strategies for various diseases, while they still encounter numerous challenges. Upon entry …

Chemoresistance remains a long-standing challenge after cancer treatment. Over the last
two decades, RNA interference (RNAi) has emerged as a gene therapy modality to sensitize …

Metal-based drugs have been used for decades to treat solid cancers; however, these drugs
have no significant therapeutic effect on glioma because they cannot effectively cross the …

Oxidative stress, characterized by the excessive accumulation of reactive oxygen species
(ROS), is linked to various pathological conditions, including myocardial infarction, cancer …