Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-
cancer analysis, identifies commonalities and differences in key biological processes that …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

A fundamental goal in evolutionary biology is to understand the genetic architecture of
adaptive traits. Using whole-genome data of 3955 of Darwin's finches on the Galápagos …

Next-generation sequencing technology provides novel opportunities for gathering genome-
scale sequence data in natural populations, laying the empirical foundation for the evolving …

Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Although quantitative PCR (qPCR) is becoming the method of choice for expression profiling
of selected genes, accurate and straightforward processing of the raw measurements …

Reverse transcription quantitative PCR (RT-qPCR) is considered today as the gold standard
for accurate, sensitive and fast measurement of gene expression. Unfortunately, what many …

Smad transcription factors lie at the core of one of the most versatile cytokine signaling
pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent …