Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Neutrophils are the most abundant leukocytes in blood and are considered to be the first line
of defense during inflammation and infections. In addition, neutrophils are also found …

Cancer cells often develop resistance to chemotherapy or irradiation through mutations in
the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular …

The death receptors Fas and tumor necrosis factor receptor 1 (TNFR1) trigger apoptosis
upon engagement by their cognate death ligands. Recently, researchers have discovered …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

The 'help'provided by CD4+ T lymphocytes during the priming of CD8+ T lymphocytes
confers a key feature of immune memory: the capacity for autonomous secondary expansion …

Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …

Natural killer T (NKT) cells constitute a distinct subpopulation of T cells with a unique antigen
specificity, prompt effector functions, and an unusual tissue distribution. NKT cells are …

T-cell mediated immune responses should be regulated to avoid the development of
autoimmune or chronic inflammatory diseases. Several mechanisms have been described …