Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer.
In recent years, numerous studies have reported the functions of cholesterol metabolism in …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality
worldwide, and its abnormal metabolism affects the survival and prognosis of patients …

Background Disturbance of cholesterol homeostasis is considered as one of the
manifestations of cancer. Cholesterol plays an essential role in the pleiotropic functions of …

Cholesterol is an essential structural component of cellular membranes. In addition to the
structural role, it also serves as a precursor to a variety of steroid hormones and has diverse …

Difenoconazole (DFZ) is a broad-spectrum triazole fungicide, that is extensively used in
agriculture. Studies have shown that residues of DFZ and other fungicides have toxic effects …

Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs,
contributing to resistance to therapies. This includes a higher demand for cholesterol, which …

Metabolic reprogramming is a hallmark of cancer progression. Metabolic activity supports
tumorigenesis and tumor progression, allowing cells to uptake essential nutrients from the …

Highlights•Dysregulated cholesterol metabolism is seen in cancer cells.•Cholesterol and its
metabolites drive tumorigenesis.•Aberrant cholesterol metabolism opens new therapeutic …

Cholesterol is considered indispensable for cell motility, but how physiological cholesterol
pools enable cells to move forward remains to be clarified. The majority of cells obtain …