Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury

AJ Ghio, JM Soukup, LA Dailey, MC Madden - Free Radical Biology and …, 2020 - Elsevier
Air pollutants cause changes in iron homeostasis through: 1) a capacity of the pollutant, or a
metabolite (s), to complex/chelate iron from pivotal sites in the cell or 2) an ability of the …

Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung

R Zakarya, I Adcock, BG Oliver - Clinical epigenetics, 2019 - Springer
In utero exposure to tobacco products, whether maternal or environmental, have harmful
effects on first neonatal and later adult respiratory outcomes. These effects have been …

Environmentally persistent free radicals: Methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences

A Aryal, A Noël, L Khachatryan, SA Cormier… - Environmental …, 2023 - Elsevier
Particulate matter (PM) containing environmentally persistent free radicals (EPFRs) results
from the incomplete combustion of organic wastes which chemisorb to transition metals. This …

[HTML][HTML] In utero exposures to electronic-cigarette aerosols impair the Wnt signaling during mouse lung development

A Noël, S Hansen, A Zaman… - … of Physiology-Lung …, 2020 - journals.physiology.org
Currently, more than 9 million American adults, including women of childbearing age, use
electronic-cigarettes (e-cigs). Further, the prevalence of maternal vaping now approaching …

[HTML][HTML] In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice

KM Cahill, TK Johnson, Z Perveen, M Schexnayder… - Toxicology, 2022 - Elsevier
There are few reports concerning electronic nicotine delivery system (ENDS) use during
pregnancy and no studies on asthma in prenatally JUUL-exposed offspring. Here, we tested …

Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function

AC Harmon, A Noël, B Subramanian… - American Journal …, 2021 - journals.physiology.org
Airborne particulate matter (PM) is associated with an increased risk for cardiovascular
diseases. Although the goal of thermal remediation is to eliminate organic wastes through …

Mmp12 Is Upregulated by in utero Second-Hand Smoke Exposures and Is a Key Factor Contributing to Aggravated Lung Responses in Adult Emphysema, Asthma …

A Noël, Z Perveen, R Xiao, H Hammond… - Frontiers in …, 2021 - frontiersin.org
Matrix metalloproteinase-12 (Mmp12) is upregulated by cigarette smoke (CS) and plays a
critical role in extracellular matrix remodeling, a key mechanism involved in physiological …

Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life

CD Onuzulu, S Lee, S Basu, J Comte… - … of Physiology-Lung …, 2023 - journals.physiology.org
Prenatal and early-life exposure to cigarette smoke (CS) has repeatedly been shown to
induce stable, long-term changes in DNA methylation (DNAm) in offspring. It has been …

Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero

A Noël, R Xiao, Z Perveen, H Zaman, V Le Donne… - Respiratory …, 2017 - Springer
Background An increasing number of epidemiological and experimental studies have
associated exposure to second-hand smoke (SHS) during pregnancy with adverse …

In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system

AM Snijders, M Zhou, TP Whitehead, B Fitch… - Clinical …, 2021 - portlandpress.com
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Thirdhand
smoke (THS) is the residual tobacco contamination that remains after the smoke clears. We …