Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Integrin adhesion complexes (IACs) have evolved over millions of years to integrate
metazoan cells physically with their microenvironment. It is presumed that the simultaneous …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

Integrin-mediated focal adhesions are the primary architectures that transmit forces between
the extracellular matrix (ECM) and the actin cytoskeleton. Although focal adhesions are …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

Plasma membrane curvature is an important factor in the regulation of cellular phenotype
and is critical for various cellular activities including the shedding of extracellular vesicles …