Iron overload in thalassemia: different organs at different rates

AT Taher, AN Saliba - Hematology 2014, the American Society …, 2017 - ashpublications.org
Thalassemic disorders lie on a phenotypic spectrum of clinical severity that depends on the
severity of the globin gene mutation and coinheritance of other genetic determinants. Iron …

[HTML][HTML] Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities

J González-Montero, R Brito, AIJ Gajardo… - World journal of …, 2018 - ncbi.nlm.nih.gov
Acute myocardial infarction (AMI) is the leading cause of death worldwide. Its associated
mortality, morbidity and complications have significantly decreased with the development of …

Indications for and adverse effects of red-cell transfusion

JL Carson, DJ Triulzi, PM Ness - New England Journal of …, 2017 - Mass Medical Soc
Indications for and Adverse Effects of Red-Cell Transfusion | NEJM Skip to main content NEJM
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Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases

R Bissinger, AAM Bhuyan, SM Qadri… - The FEBS …, 2019 - Wiley Online Library
The average lifespan of circulating erythrocytes usually exceeds hundred days. Prior to that,
however, erythrocytes may be exposed to oxidative stress in the circulation which could …

Sickle cell disease

RE Ware, M de Montalembert, L Tshilolo, MR Abboud - The Lancet, 2017 - thelancet.com
Sickle cell disease is a common and life-threatening haematological disorder that affects
millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in …

Liver iron quantification with MR imaging: a primer for radiologists

R Labranche, G Gilbert, M Cerny, KN Vu, D Soulières… - Radiographics, 2018 - pubs.rsna.org
Iron overload is a systemic disorder and is either primary (genetic) or secondary (exogenous
iron administration). Primary iron overload is most commonly associated with hereditary …

Practical guide to quantification of hepatic iron with MRI

B Henninger, J Alustiza, M Garbowski, Y Gandon - European radiology, 2020 - Springer
Our intention is to demystify the MR quantification of hepatic iron (ie, the liver iron
concentration) and give you a step-by-step approach by answering the most pertinent …

The role of deferiprone in iron chelation

RC Hider, AV Hoffbrand - New England Journal of Medicine, 2018 - Mass Medical Soc
The Role of Deferiprone in Iron Chelation | NEJM Skip to main content NEJM Group Follow Us
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Ineffective erythropoiesis and regulation of iron status in iron loading anaemias

C Camaschella, A Nai - British journal of haematology, 2016 - Wiley Online Library
The definition 'iron loading anaemias' encompasses a group of inherited and acquired
anaemias characterized by ineffective erythropoiesis, low hepcidin levels, excessive iron …

How we manage patients with pyruvate kinase deficiency

RF Grace, D Mark Layton… - British journal of …, 2019 - Wiley Online Library
Novel therapies in development have brought a new focus on pyruvate kinase deficiency
(PKD), the most common congenital haemolytic anaemia due to a glycolytic enzyme …