In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

The implementation of endotype-driven effective intervention strategies is now considered
as an essential component for sepsis management. Rapid screening and frequent …

Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and
the concurrent release of damage-associated molecular patterns (DAMPs). Collectively …

Background Treatment of severely ill COVID-19 patients requires simultaneous
management of oxygenation and inflammation without compromising viral clearance. While …

Background Sepsis is a heterogeneous syndrome, and the identification of clinical
subphenotypes is essential. Although organ dysfunction is a defining element of sepsis …

Background Acute respiratory distress syndrome (ARDS), a life-threatening condition
characterized by hypoxemia and poor lung compliance, is associated with high mortality …

Metabolic reprogramming of innate immune cells occurs during both the hyperinflammatory
and immunotolerant phases of sepsis. The hypoxia inducible factor (HIF) signaling pathway …

Multiple studies have investigated the role of blood circulating proteins in COVID-19 disease
using the Olink affinity proteomics platform. However, study inclusion criteria and sample …

Systemic infections, especially in patients with chronic diseases, may result in sepsis: an
explosive, uncoordinated immune response that can lead to multisystem organ failure with a …

Vascular injury is a well-established, disease-modifying factor in acute respiratory distress
syndrome (ARDS) pathogenesis. Recently, coronavirus disease 2019 (COVID-19)–induced …