A new and promising tool in membrane research is the detergent-free solubilization of
membrane proteins by styrene–maleic acid copolymers (SMAs). These amphipathic …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Despite the great importance of membrane proteins, structural and functional studies of
these proteins present major challenges. A significant hurdle is the extraction of the …

Once removed from their natural environment, membrane proteins depend on membrane‐
mimetic systems to retain their native structures and functions. To this end, lipid‐bilayer …

For some membrane proteins, detergent-mediated solubilization compromises protein
stability and functionality, often impairing biophysical and structural analyses. Hence …

The styrene-maleic acid (SMA) copolymer is rapidly gaining attention as a tool in membrane
research, due to its ability to directly solubilize lipid membranes into nanodisk particles …

The use of styrene–maleic acid (SMA) copolymers to extract and purify transmembrane
proteins, while retaining their native bilayer environment, overcomes many of the …

The use of styrene maleic acid co-polymer (SMA) for membrane protein extraction and
purification has grown in recent years. SMA inserts in the membrane and assembles into …

The fundamental importance of membrane proteins in drug discovery has meant that
membrane mimetic systems for studying membrane proteins are of increasing interest. One …

Atomic-resolution structural studies of membrane-associated proteins and peptides in a
membrane environment are important to fully understand their biological function and the …