One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

Natural drug-based chemotherapeutic have advanced at an unprecedented rate over the
past decade. Owing to protective roles in vegetation, and exceptional antioxidant qualities …

Metal-free synthesis of highly functionalized (E)-stilbenes cored with electronic donor and
acceptor functionalities was achieved through a carbanion-induced ring transformation …

Microtubules (composed of α-and β-tubulin heterodimers) ubiquitous cellular polymers are
important components of the cytoskeleton and play diverse roles within the cell, such as …

The development of multidrug resistance (MDR) is a major cause of failure in cancer
chemotherapy. Several abietane diterpenes with antitumoral activities have been isolated …

Abstract Combretastatin A-4 (CA-4) is a highly cytotoxic natural product and several
derivatives have been prepared which underwent clinical trial. These investigations …

The current review discusses the importance of combretastatin A-4 (CA-4) as a lead
compound of microtubule targeting agents. CA-4 holds a unique place among naturally …

Natural ingredients have been used in skincare products for thousands of years. The current
focus is on novel natural bioactivities that shield the skin from UV rays and free radicals …

Background Paeonia suffruticosa is an important traditional Chinese herb used to treat
osteoarthritis (OA) and oligostilbenes are the main active ingredient of the seeds of P …

The chemical investigation of the roots and stems of Combretum laxum yielded a new
dihydrostilbene derivative, 4′-hydroxy-3, 3′, 4-trimethoxy-5-(3, 4, 5-trimethoxyphenoxy) …