Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

L Gorgannezhad, M Umer, MN Islam, NT Nguyen… - Lab on a Chip, 2018 - pubs.rsc.org
Cell-free DNA (cfDNA) refers to short fragments of acellular nucleic acids detectable in
almost all body fluids, including blood, and is involved in various physiological and …

A comprehensive overview on alkaline phosphatase targeting and reporting assays

SM Shaban, SB Jo, E Hafez, JH Cho, DH Kim - Coordination Chemistry …, 2022 - Elsevier
Alkaline phosphatase (ALP) is an enzyme that catalyzes the dephosphorylation of various
vital nucleic acids and proteins. A broad range of physiological and pathological processes …

Advanced liquid biopsy technologies for circulating biomarker detection

N Soda, BHA Rehm, P Sonar, NT Nguyen… - Journal of Materials …, 2019 - pubs.rsc.org
Liquid biopsy is a new diagnostic concept that provides important information for monitoring
and identifying tumor genomes in body fluid samples. Detection of tumor origin …

DNA clutch probes for circulating tumor DNA analysis

J Das, I Ivanov, EH Sargent… - Journal of the American …, 2016 - ACS Publications
Progress toward the development of minimally invasive liquid biopsies of disease is being
bolstered by breakthroughs in the analysis of circulating tumor DNA (ctDNA): DNA released …

Assays for alkaline phosphatase that use L-ascorbic acid 2-phosphate as a substrate

Y Wu, W Chen, C Wang, D Xing - Coordination Chemistry Reviews, 2023 - Elsevier
Alkaline phosphatase (ALP) is a zinc-containing metalloprotein widely distributed in
mammalian tissues that catalyzes the dephosphorylation of a wide variety of phosphorylated …

[HTML][HTML] Current advances in detecting genetic and epigenetic biomarkers of colorectal cancer

MS Islam, V Gopalan, AK Lam, MJA Shiddiky - Biosensors and …, 2023 - Elsevier
Colorectal carcinoma (CRC) is the third most common cancer in terms of diagnosis and the
second in terms of mortality. Recent studies have shown that various proteins, extracellular …

Recent advances in liquid biopsy technologies for cancer biomarker detection

N Soda, K Clack, MJA Shiddiky - Sensors & Diagnostics, 2022 - pubs.rsc.org
Gene mutation is associated with cancer and the dissemination of circulating biomarkers
through the blood represents a vital transitional step that exemplifies the shift from localized …

Ultrasensitive electrochemical detection of miRNA-21 using a zinc finger protein specific to DNA–RNA hybrids

CS Fang, K Kim, B Yu, S Jon, MS Kim… - Analytical …, 2017 - ACS Publications
Both high sensitivity and high specificity are crucial for detection of miRNAs that have
emerged as important clinical biomarkers. Just Another Zinc finger proteins (JAZ, ZNF346) …

Recent advancements in the utilization of indium tin oxide (ITO) in electroanalysis without surface modification

MR Akanda, AM Osman, MK Nazal… - Journal of The …, 2020 - iopscience.iop.org
Indium tin oxide (ITO), as an electrode, has superiority over metal electrodes commonly
used for electroanalysis due to its low cost, low electrochemical background response, wide …

Graphene oxide-based simple and rapid detection of antibiotic resistance gene via quantum dot-labeled zinc finger proteins

DT Ha, VT Nguyen, MS Kim - Analytical chemistry, 2021 - ACS Publications
With the increasing rise of antibiotic-resistant pathogens, a simple and rapid detection of
antibiotic resistance gene (ARG) is crucial to mitigate the spreading of antibiotic resistance …