Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

To date, vaccination has become one of the most effective strategies to control and reduce
infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were …

Biocontainment systems that couple environmental sensing with circuit-based control of cell
viability could be used to prevent escape of genetically modified microbes into the …

Lactic acid bacteria (LAB) have a long history of use in the food industry. Some species are
part of the normal human microbiota and have beneficial properties for human health. Their …

Since the emergence of the biopharmaceutical industry in the 1980's, Escherichia coli, has
played an important role in the industrial production of recombinant proteins and plasmid …

Inherited retinal dystrophies and optic neuropathies cause chronic disabling loss of visual
function. The development of recombinant adeno-associated viral vectors (rAAV) gene …

Genomic integration techniques offer opportunities for generation of engineered
microorganisms with improved or even entirely new functions but are currently limited by …

Chromosomal integration of recombinant genes is desirable compared with expression from
plasmids due to increased stability, reduced cell-to-cell variability, and elimination of the …

Abstract Lacto-N-fucopentaose I (LNFP I), a member of the fucosylated human milk
oligosaccharides (HMOs) family, has received widespread attention because of its …

Drug delivery systems based on genetically engineered oncolytic bacteria have properties
that cannot be achieved by traditional therapeutic interventions. Thus, they have attracted …