The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …

FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in
human cancers,,,–. However, the role and the molecular mechanisms by which FAT1 …

Patient-derived tumor xenografts (PDXs), in which tumor fragments surgically dissected from
cancer patients are directly transplanted into immunodeficient mice, have emerged as a …

Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction.
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Squamous cell lung cancers (lung squamous cell carcinomas [LUSCs]) are associated with
high mortality and a lack of therapies specific to this disease. Although recurrent molecular …

Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …