Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The
production and deposition of Aβ are important factors affecting AD progression and …

The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the
sporadic forms of Alzheimer's and Parkinson's disease—are increasing worldwide. Notably …

Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural
plasticity and improve cognitive impairment. The purpose of this study was to investigate the …

Alzheimer disease (AD) is a complex neurodegenerative disorder with no definite treatment.
The expression of miR-29 family is significantly reduced in AD, suggesting a part for the …

Pathogenesis of neurodegenerative diseases involves dysfunction of mitochondria, one of
the most important cell organelles in the brain, with its most prominent roles in producing …

Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated
stress response (ISR) via multiple pathologies including neuronal hyperactivation …

Intracellular neurofibrillary tangles (NFTs) composed of tau protein are a neuropathological
hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's …

The increased healthspan afforded by coffee intake provides novel opportunities to identify
new therapeutic strategies. Caffeine has been proposed to afford benefits through …

Pathologic, biochemical and genetic evidence indicates that accumulation and aggregation
of amyloid β-proteins (Aβ) is a critical factor in the pathogenesis of Alzheimer's disease (AD) …

Abstract Alzheimer's disease (AD), a neurodegenerative condition previously known to affect
the older population, is also now seen in younger individuals. AD is often associated with …