Sphingolipids and lipid rafts: Novel concepts and methods of analysis

E Bieberich - Chemistry and physics of lipids, 2018 - Elsevier
About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

Ceramide: a simple sphingolipid with unique biophysical properties

BM Castro, M Prieto, LC Silva - Progress in lipid research, 2014 - Elsevier
Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …

Membrane lipid nanodomains

M Cebecauer, M Amaro, P Jurkiewicz… - Chemical …, 2018 - ACS Publications
Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

[HTML][HTML] Effect of ceramide structure on membrane biophysical properties: the role of acyl chain length and unsaturation

SN Pinto, LC Silva, AH Futerman, M Prieto - Biochimica et Biophysica Acta …, 2011 - Elsevier
Ceramide is an important bioactive sphingolipid involved in a variety of biological
processes. The mechanisms by which ceramide regulates biological events are not fully …

[HTML][HTML] Effects of ceramide and other simple sphingolipids on membrane lateral structure

FM Goñi, A Alonso - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2009 - Elsevier
The available data concerning the ability of ceramide and other simple sphingolipids to
segregate laterally into rigid, gel-like domains in a fluid bilayer has been reviewed …

Optical control of lipid rafts with photoswitchable ceramides

JA Frank, HG Franquelim, P Schwille… - Journal of the American …, 2016 - ACS Publications
Ceramide is a pro-apoptotic sphingolipid with unique physical characteristics. Often viewed
as a second messenger, its generation can modulate the structure of lipid rafts. We prepared …

[HTML][HTML] Phase diagram and tie-line determination for the ternary mixture DOPC/eSM/cholesterol

N Bezlyepkina, RS Gracià, P Shchelokovskyy… - Biophysical …, 2013 - cell.com
We propose a novel, to our knowledge, method for the determination of tie lines in a phase
diagram of ternary lipid mixtures. The method was applied to a system consisting of …

[HTML][HTML] Regulation of the cancer cell membrane lipid composition by NaCHOleate: Effects on cell signaling and therapeutical relevance in glioma

V Lladó, DJ López, M Ibarguren, M Alonso… - … et Biophysica Acta (BBA …, 2014 - Elsevier
This review summarizes the cellular bases of the effects of NaCHOleate (2-hydroxyoleic
acid; 2OHOA; Minerval) against glioma and other types of tumors. NaCHOleate, activates …

[HTML][HTML] Binding of LL-37 to model biomembranes: insight into target vs host cell recognition

R Sood, Y Domanov, M Pietiäinen, VP Kontinen… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Pursuing the molecular mechanisms of the concentration dependent cytotoxic and hemolytic
effects of the human antimicrobial peptide LL-37 on cells, we investigated the interactions of …

Membrane lipid domains and rafts: current applications of fluorescence lifetime spectroscopy and imaging

RFM de Almeida, LMS Loura, M Prieto - Chemistry and physics of lipids, 2009 - Elsevier
Membrane microdomains and their involvement in cellular processes are part of the current
paradigm of biomembranes. However, a better characterization of domains, namely lipid …