Abstract The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR;
however, its function was unknown. Subsequent studies suggest that the MC4R might be …

The physiological mechanisms that control energy balance are reciprocally linked to those
that control reproduction, and together, these mechanisms optimize reproductive success …

Kisspeptin stimulates reproduction, and kisspeptin cells in the arcuate nucleus (ARC)
express Ob-Rb in the mouse. Herein we report studies in ewes to determine whether …

The regulation of food intake in fish is a complex process carried out through several
different mechanisms in the central nervous system (CNS) with hypothalamus being the …

The cocaine-and amphetamine-regulated transcript (CART) has been the subject of
significant interest for over a decade. Work to decipher the detailed mechanism of CART …

Posttranscriptional processing of proopiomelanocortin (POMC) yields melanocortin
peptides, which are involved in the regulation of energy balance in mammals. The sequence …

Intracerebroventricular injection of oxytocin (Oxt), a neuropeptide produced in hypothalamic
paraventricular (PVN) and supraoptic nuclei (SON), melanocortin-dependently suppresses …

Melanocortin signalling is mediated by binding to a family of G protein-coupled receptors
that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC1 …

To further test the hypothesis that melanocortins stimulate the reproductive axis, we treated
ewes with melanocortin agonist (MTII) in the luteal phase of the estrous cycle and during …

The arcuate nucleus is generally conserved across vertebrate taxa in its neuroanatomy and
neuropeptide expression. Gene expression of agouti-related protein (AGRP), neuropeptide …