Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

Colorectal cancer in inflammatory bowel disease: mechanisms and management

SC Shah, SH Itzkowitz - Gastroenterology, 2022 - Elsevier
Patients with inflammatory bowel disease (IBD) are at increased risk of developing
colorectal cancer (CRC), despite decreases in CRC incidence in recent years. Chronic …

Human gut microbiota in health and disease: Unveiling the relationship

M Afzaal, F Saeed, YA Shah, M Hussain… - Frontiers in …, 2022 - frontiersin.org
The human gut possesses millions of microbes that define a complex microbial community.
The gut microbiota has been characterized as a vital organ forming its multidirectional …

The inflammatory pathogenesis of colorectal cancer

M Schmitt, FR Greten - Nature Reviews Immunology, 2021 - nature.com
The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

The intestinal microbiota and colorectal cancer

Y Cheng, Z Ling, L Li - Frontiers in immunology, 2020 - frontiersin.org
The intestinal microbiota, composed of a large population of microorganisms, is often
considered a “forgotten organ” in human health and diseases. Increasing evidence indicates …

Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

[HTML][HTML] Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

W Fong, Q Li, J Yu - Oncogene, 2020 - nature.com
Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging
field of study. Gut microbiota modulation, with the aim to reverse established microbial …

Host–microbiota maladaptation in colorectal cancer

A Janney, F Powrie, EH Mann - Nature, 2020 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

SH Wong, J Yu - Nature Reviews Gastroenterology & Hepatology, 2019 - nature.com
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …

Dysbiosis of human gut microbiome in young-onset colorectal cancer

Y Yang, L Du, D Shi, C Kong, J Liu, G Liu, X Li… - Nature …, 2021 - nature.com
The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant
knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients …