Dietary carbohydrates and lipids in the pathogenesis of leaky gut syndrome: An overview
A Binienda, A Twardowska, A Makaro… - International journal of …, 2020 - mdpi.com
This review summarizes the recent knowledge on the effects of dietary carbohydrates and
lipids on the pathophysiology of leaky gut syndrome (LGS). Alterations in intestinal barrier …
lipids on the pathophysiology of leaky gut syndrome (LGS). Alterations in intestinal barrier …
Recent Advances in the Role of Sphingosine 1‐phosphate in Cancer
Sphingosine 1‐phosphate (S1P) is a bioactive lipid that binds to a family of G protein‐
coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional …
coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional …
Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1
Cancer stem cells (CSCs) represent rare tumor cell populations capable of self-renewal,
differentiation, and tumor initiation and are highly resistant to chemotherapy and …
differentiation, and tumor initiation and are highly resistant to chemotherapy and …
The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism
Abstract Sphingosine 1-phosphate (S1P) is a signaling lipid that has broad roles, working
either intracellularly through various protein targets, or extracellularly via a family of five G …
either intracellularly through various protein targets, or extracellularly via a family of five G …
Qing‐Fei‐Pai‐Du decoction and wogonoside exert anti‐inflammatory action through down‐regulating USP14 to promote the degradation of activating transcription …
X Xu, J Xia, S Zhao, Q Wang, G Ge, F Xu… - The FASEB …, 2021 - Wiley Online Library
COVID‐19 is often characterized by dysregulated inflammatory and immune responses. It
has been shown that the Traditional Chinese Medicine formulation Qing‐Fei‐Pai‐Du …
has been shown that the Traditional Chinese Medicine formulation Qing‐Fei‐Pai‐Du …
Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines
We combined functional genomics and human genetics to investigate processes that affect
type 1 diabetes (T1D) risk by mediating beta cell survival in response to proinflammatory …
type 1 diabetes (T1D) risk by mediating beta cell survival in response to proinflammatory …
A novel selective sphingosine kinase 2 inhibitor, HWG-35D, ameliorates the severity of imiquimod-induced psoriasis model by blocking Th17 differentiation of naive …
Sphingosine kinases (SK) catalyze the phosphorylation of sphingosine to generate
sphingosine-1-phosphate. Two isoforms of SK (SK1 and SK2) exist in mammals. Previously …
sphingosine-1-phosphate. Two isoforms of SK (SK1 and SK2) exist in mammals. Previously …
Signaling controversy and future therapeutical perspectives of targeting sphingolipid network in cancer immune editing and resistance to tumor necrosis factor-α …
OA Sukocheva, ME Neganova, Y Aleksandrova… - Cell Communication and …, 2024 - Springer
Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine
signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing …
signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing …
[HTML][HTML] Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation
It has been well-established that cancer cells often display altered metabolic profiles, and
recent work has concentrated on how cancer cells adapt to serine removal. Serine can be …
recent work has concentrated on how cancer cells adapt to serine removal. Serine can be …
Druggable sphingolipid pathways: experimental models and clinical opportunities
VA Blaho - Druggable lipid signaling pathways, 2020 - Springer
Intensive research in the field of sphingolipids has revealed diverse roles in cell biological
responses and human health and disease. This immense molecular family is primarily …
responses and human health and disease. This immense molecular family is primarily …