Despite the undisputed development of medicine, antibiotics still serve as first-choice drugs
for patients with infectious disorders. The widespread use of antibiotics results from a wide …

Xeno nucleic acids (XNA) are an increasingly important class of hypermodified nucleic acids
with great potential in bioorganic chemistry and synthetic biology. Glycol nucleic acid (GNA) …

Chemical modification of aptamers is an important step to improve their performance and
stability in biological media. This can be performed either during their identification (mod …

Development of nucleic acids containing unnatural moieties has expanded the scope of
genetic materials, and modifications of nucleobases have been extensively explored and …

Photodynamic therapy (PDT) is an approved cancer treatment modality. Despite its high
efficiency, PDT is limited in terms of specificity and by the poor solubility of the rather …

Bacterial natural products containing heptosides such as septacidin represent interesting
scaffolds for the development of drugs to combat antimicrobial resistance. However, very few …

A better understanding of the RNA biology and chemistry is necessary to then develop new
RNA therapeutic strategies. This review is the synthesis of a series of conferences that took …

Decorating nucleic acids with boronic acids can extend the usefulness of oligonucleotide-
based tools to the development of medical imaging agents, the promotion of binding of …

DNA microarrays are very useful tools to study the realm of nucleic acids interactions at high
throughput. The conventional approach to microarray synthesis employs phosphoramidite …