Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Antiangiogenic and cytotoxic effects are considered the principal mechanisms of action of
sorafenib, a multitarget kinase inhibitor approved for the treatment of hepatocellular …

The mammalian liver is composed of repeating hexagonal units termed lobules. Spatially
resolved single-cell transcriptomics has revealed that about half of hepatocyte genes are …

Transcription modulated by the circadian clock is diverse across cell types, underlying
circadian control of peripheral metabolism and its observed perturbation in human diseases …

There is extensive evidence supporting the interplay between metabolism and immune
response, that have evolved in close relationship, sharing regulatory molecules and …

Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, being
frequently associated with obesity, unbalanced dietary regimens, and reduced physical …

Cell‐fate determination is influenced by interactions between master transcription factors
(TFs) and cis‐regulatory elements. Hepatocyte nuclear factor 4 alpha (HNF4A), a liver …

While most gene transcription yields RNA transcripts that code for proteins, a sizable
proportion of the genome generates RNA transcripts that do not code for proteins, but may …

β‐catenin signaling can be both a physiological and oncogenic pathway in the liver. It
controls compartmentalized gene expression, allowing the liver to ensure its essential …