Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …

Pathogenic bacteria must withstand diverse host environments during infection.
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …

Lag phase represents the earliest and most poorly understood stage of the bacterial growth
cycle. We developed a reproducible experimental system and conducted functional genomic …

Serovars of Salmonella enterica are frequent agents of foodborne disease worldwide. They
are capable of growing and surviving in numerous natural, commercial and host environs …

Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated with
the bacterial nucleoid. We used chromatin immunoprecipitation to determine the binding …

Both prokaryotic and eukaryotic organisms contain DNA bridging proteins, which can have
regulatory or architectural functions. The molecular and mechanical details of such proteins …

Lateral gene transfer has played a prominent role in bacterial evolution, but the mechanisms
allowing bacteria to tolerate the acquisition of foreign DNA have been incompletely defined …

Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar
Typhimurium has a key role in selectively silencing the transcription of large numbers of …

H-NS is a protein of the bacterial nucleoid involved in DNA compaction and transcription
regulation. In vivo, H-NS selectively silences specific genes of the bacterial chromosome …

The histone-like nucleoid structuring (H-NS) protein plays a fundamental role in DNA
condensation and is a key regulator of enterobacterial gene expression in response to …