Only a small fraction of patients respond to the drug prescribed to treat their disease, which
means that most are at risk of unnecessary exposure to side effects through ineffective …

Plants regulate molecular bioactivity in response to daily and seasonal environmental
fluctuations in temperature, light, humidity, and precipitation. These rhythms interconnect …

In rice, a small increase in nighttime temperature reduces grain yield and quality. How warm
nighttime temperatures (WNT) produce these detrimental effects is not well understood …

Statistical and machine learning (ML)-based methods have recently advanced in
construction of gene regulatory network (GRNs) based on high-throughput biological …

Highlights•GRNs represent causal relationships among regulators and their downstream
genes.•Biological hypothesis drives data collection and the subsequent inferred …

All aspects of transcription and its regulation involve dynamic events. However, capturing
these dynamic events in gene regulatory networks (GRNs) offers both a promise and a …

As sessile organisms, plants are finely tuned to respond dynamically to developmental,
circadian and environmental cues. Genome‐wide studies investigating these types of cues …

Recent advances in genomic technologies have generated data on large-scale protein–
DNA interactions and open chromatin regions for many eukaryotic species. How to identify …

RNA-seq has become a state-of-the-art technique for transcriptomic studies. Advances in
both RNA-seq techniques and the corresponding analysis tools and pipelines have …

Through complex interspecies interactions, microbial processes drive nutrient cycling and
biogeochemistry. However, we still struggle to predict specifically which organisms …