Modeling neoplastic disease with spheroids and organoids

M Zanoni, M Cortesi, A Zamagni, C Arienti… - Journal of hematology & …, 2020 - Springer
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Patient-derived glioma models: from patients to dish to animals

CC da Hora, MW Schweiger, T Wurdinger, BA Tannous - Cells, 2019 - mdpi.com
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …

BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair

S Zhang, X Peng, X Li, H Liu, B Zhao, M Elkabets… - Cell death & …, 2021 - nature.com
PARP inhibitors have been approved for the therapy of cancers with homologous
recombination (HR) deficiency based on the concept of “synthetic lethality”. However …

Glioblastoma research on zebrafish xenograft models: a systematic review

A Pliakopanou, I Antonopoulos, N Darzenta… - Clinical and …, 2024 - Springer
Glioblastoma (GBM) constitutes the most common primary brain tumor in adults. The
challenges in GBM therapeutics have shed light on zebrafish used as a promising animal …

Preclinical models of glioblastoma: Limitations of current models and the promise of new developments

P Liu, S Griffiths, D Veljanoski… - Expert Reviews in …, 2021 - cambridge.org
Glioblastoma (GBM) is the most common and aggressive primary brain tumour, yet little
progress has been made towards providing better treatment options for patients diagnosed …

Tipping the scales with zebrafish to understand adaptive tumor immunity

KZ Miao, GY Kim, GK Meara, X Qin… - Frontiers in cell and …, 2021 - frontiersin.org
The future of improved immunotherapy against cancer depends on an in-depth
understanding of the dynamic interactions between the immune system and tumors. Over …

Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

S Benson, F De Moliner, A Fernandez, E Kuru… - Nature …, 2021 - nature.com
Photoactivatable molecules enable ablation of malignant cells under the control of light, yet
current agents can be ineffective at early stages of disease when target cells are similar to …

Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model

SM Saraiva, C Gutiérrez-Lovera, J Martínez-Val… - Scientific Reports, 2021 - nature.com
Triple negative breast cancer (TNBC) is known for being very aggressive, heterogeneous
and highly metastatic. The standard of care treatment is still chemotherapy, with adjacent …

Cellular and molecular mechanisms underlying glioblastoma and zebrafish models for the discovery of new treatments

P Reimunde, A Pensado-López, M Carreira Crende… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is one of the greatest challenges facing neuro-
oncology today. Current treatments are far from satisfactory and, given the poor prognosis of …

Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry

GL Liguori - Cells, 2024 - mdpi.com
Glioblastoma (GB) is a rare but extremely aggressive brain tumor that significantly impacts
patient outcomes, affecting both duration and quality of life. The protocol established by …