Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
Patient-derived glioma models: from patients to dish to animals
CC da Hora, MW Schweiger, T Wurdinger, BA Tannous - Cells, 2019 - mdpi.com
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …
associated with a poor survival. Current standard of care consists of surgical resection …
BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair
S Zhang, X Peng, X Li, H Liu, B Zhao, M Elkabets… - Cell death & …, 2021 - nature.com
PARP inhibitors have been approved for the therapy of cancers with homologous
recombination (HR) deficiency based on the concept of “synthetic lethality”. However …
recombination (HR) deficiency based on the concept of “synthetic lethality”. However …
Glioblastoma research on zebrafish xenograft models: a systematic review
A Pliakopanou, I Antonopoulos, N Darzenta… - Clinical and …, 2024 - Springer
Glioblastoma (GBM) constitutes the most common primary brain tumor in adults. The
challenges in GBM therapeutics have shed light on zebrafish used as a promising animal …
challenges in GBM therapeutics have shed light on zebrafish used as a promising animal …
Preclinical models of glioblastoma: Limitations of current models and the promise of new developments
P Liu, S Griffiths, D Veljanoski… - Expert Reviews in …, 2021 - cambridge.org
Glioblastoma (GBM) is the most common and aggressive primary brain tumour, yet little
progress has been made towards providing better treatment options for patients diagnosed …
progress has been made towards providing better treatment options for patients diagnosed …
Tipping the scales with zebrafish to understand adaptive tumor immunity
KZ Miao, GY Kim, GK Meara, X Qin… - Frontiers in cell and …, 2021 - frontiersin.org
The future of improved immunotherapy against cancer depends on an in-depth
understanding of the dynamic interactions between the immune system and tumors. Over …
understanding of the dynamic interactions between the immune system and tumors. Over …
Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
Photoactivatable molecules enable ablation of malignant cells under the control of light, yet
current agents can be ineffective at early stages of disease when target cells are similar to …
current agents can be ineffective at early stages of disease when target cells are similar to …
Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model
SM Saraiva, C Gutiérrez-Lovera, J Martínez-Val… - Scientific Reports, 2021 - nature.com
Triple negative breast cancer (TNBC) is known for being very aggressive, heterogeneous
and highly metastatic. The standard of care treatment is still chemotherapy, with adjacent …
and highly metastatic. The standard of care treatment is still chemotherapy, with adjacent …
Cellular and molecular mechanisms underlying glioblastoma and zebrafish models for the discovery of new treatments
P Reimunde, A Pensado-López, M Carreira Crende… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is one of the greatest challenges facing neuro-
oncology today. Current treatments are far from satisfactory and, given the poor prognosis of …
oncology today. Current treatments are far from satisfactory and, given the poor prognosis of …
Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry
GL Liguori - Cells, 2024 - mdpi.com
Glioblastoma (GB) is a rare but extremely aggressive brain tumor that significantly impacts
patient outcomes, affecting both duration and quality of life. The protocol established by …
patient outcomes, affecting both duration and quality of life. The protocol established by …