Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites,
including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and …

One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly
specialised, apical secretory organelles, called the micronemes and rhoptries that play …

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is
caused by the intracellular parasite Plasmodium. However, increased resistance to ACT …

Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium.
Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

The fight against malaria is a continuum as the epidemic is not abating. For proper
deployment of tools in the fight against malaria, an assessment of the situation is necessary …

Calcium signaling regulated by the cGMP-dependent protein kinase (PKG) controls key life
cycle transitions in the malaria parasite. However, how calcium is mobilized from …

The pathology of malaria is caused by infection of red blood cells with unicellular
Plasmodium parasites. During blood-stage development, the parasite replicates within a …

Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to
barrier penetration, tissue dissemination, inflammation, and pathogen transmission. Like cell …

Several measures are in place to combat the worldwide spread of malaria, especially in
regions of high endemicity. In part, most common antimalarials, such as quinolines and …