[HTML][HTML] STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
I Tošić, DA Frank - Neoplasia, 2021 - Elsevier
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3)
is activated constitutively in a wide array of human cancers. It is an appealing molecular …
is activated constitutively in a wide array of human cancers. It is an appealing molecular …
[HTML][HTML] Targeting the JAK/STAT pathway in solid tumors
Z Qureshy, DE Johnson, JR Grandis - Journal of cancer metastasis …, 2020 - ncbi.nlm.nih.gov
Aberrant activation of signal transducer and activator of transcription (STAT) proteins is
associated with the development and progression of solid tumors. However, as transcription …
associated with the development and progression of solid tumors. However, as transcription …
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo
A Kaneshige, L Bai, M Wang, D McEachern… - Nature Chemical …, 2023 - nature.com
Signal transducer and activator of transcription 5 (STAT5) is an attractive therapeutic target,
but successful targeting of STAT5 has proved to be difficult. Here we report the development …
but successful targeting of STAT5 has proved to be difficult. Here we report the development …
Decoding IL-23 signaling cascade for new therapeutic opportunities
G Pastor-Fernández, IR Mariblanca, MN Navarro - Cells, 2020 - mdpi.com
The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …
Paradoxical functions of long noncoding RNAs in modulating STAT3 signaling pathway in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the lethal and leading types of cancer threatening
the globe with a high mortality rate. STAT3 is an oncogenic transcription factor that is …
the globe with a high mortality rate. STAT3 is an oncogenic transcription factor that is …
STAT3 pathway in gastric cancer: signaling, therapeutic targeting and future prospects
M Ashrafizadeh, A Zarrabi, S Orouei, V Zarrin… - Biology, 2020 - mdpi.com
Molecular signaling pathways play a significant role in the regulation of biological
mechanisms, and their abnormal expression can provide the conditions for cancer …
mechanisms, and their abnormal expression can provide the conditions for cancer …
Discovery and repurposing of artemisinin
Q Shi, F Xia, Q Wang, F Liao, Q Guo, C Xu, J Wang - Frontiers of medicine, 2022 - Springer
Malaria is an ancient infectious disease that threatens millions of lives globally even today.
The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in …
The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in …
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma
Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐
homing mature T‐cells causing severe symptoms and high mortality through chronic …
homing mature T‐cells causing severe symptoms and high mortality through chronic …
Involvement of STAT5 in Oncogenesis
CE Halim, S Deng, MS Ong, CT Yap - Biomedicines, 2020 - mdpi.com
Signal transducer and activator of transcription (STAT) proteins, and in particular STAT3,
have been established as heavily implicated in cancer. Recently, the involvement of STAT5 …
have been established as heavily implicated in cancer. Recently, the involvement of STAT5 …
Activation of STAT3 and STAT5 signaling in epithelial ovarian cancer progression: mechanism and therapeutic opportunity
Epithelial ovarian cancer (EOC) is the most lethal of all gynecologic malignancies. Despite
advances in surgical and chemotherapeutic options, most patients with advanced EOC have …
advances in surgical and chemotherapeutic options, most patients with advanced EOC have …