Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it
maintains plasma sodium concentration, arterial blood pressure and extracellular volume …

Serpins are a superfamily of proteins characterized by their common function as serine
protease inhibitors. So far, 36 serpins from nine clades have been identified. These proteins …

Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD):
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum
(ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the …

Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin)
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …

Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease
characterised by unregulated proteolytic destruction of lung tissue mediated via a protease …

Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However,
genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost …

Serpins represent the most broadly distributed superfamily of proteases inhibitors. They
contribute to a variety of physiological functions and any alteration of the serpin-protease …

Objective To assess the effect of serine protein inhibitor A3N (serpinA3N) in ischemic stroke
and to explore its mechanism of action. Methods Mouse ischemic stroke model was induced …

The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of
research of tick protease inhibitors, which represent important constituents of the proteins …