Targeting TGFβ signal transduction for cancer therapy
S Liu, J Ren, P Ten Dijke - Signal transduction and targeted therapy, 2021 - nature.com
Transforming growth factor-β (TGFβ) family members are structurally and functionally related
cytokines that have diverse effects on the regulation of cell fate during embryonic …
cytokines that have diverse effects on the regulation of cell fate during embryonic …
TGF-β receptors: In and beyond TGF-β signaling
A Vander Ark, J Cao, X Li - Cellular signalling, 2018 - Elsevier
Transforming growth factor β (TGF-β) plays an important role in normal development and
homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling …
homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling …
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling
F Xie, X Zhou, P Su, H Li, Y Tu, J Du, C Pan… - Nature …, 2022 - nature.com
Cancer immunotherapies have shown clinical success in various types of tumors but the
patient response rate is low, particularly in breast cancer. Here we report that malignant …
patient response rate is low, particularly in breast cancer. Here we report that malignant …
TGF-β signaling from receptors to Smads
A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β
Y Lan, D Zhang, C Xu, KW Hance, B Marelli… - Science translational …, 2018 - science.org
Antibodies targeting immune checkpoints are emerging as potent and viable cancer
therapies, but not all patients respond to these as single agents. Concurrently targeting …
therapies, but not all patients respond to these as single agents. Concurrently targeting …
TGF-β family signaling in tumor suppression and cancer progression
J Seoane, RR Gomis - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
TGF-β-induced endothelial to mesenchymal transition in disease and tissue engineering
J Ma, G Sanchez-Duffhues, MJ Goumans… - Frontiers in cell and …, 2020 - frontiersin.org
Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …
rise to cells with multipotent potential. EndMT is essential for the formation of the …
Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications
ŁA Poniatowski, P Wojdasiewicz, R Gasik… - Mediators of …, 2015 - Wiley Online Library
The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …
Reactivation of hippocampal ensemble memories during sleep
MA Wilson, BL McNaughton - Science, 1994 - science.org
Simultaneous recordings were made from large ensembles of hippocampal" place cells" in
three rats during spatial behavioral tasks and in slow-wave sleep preceding and following …
three rats during spatial behavioral tasks and in slow-wave sleep preceding and following …
TGF-β signal transduction
J Massagué - Annual review of biochemistry, 1998 - annualreviews.org
The transforming growth factor β (TGF-β) family of growth factors control the development
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …