One of the most powerful strategies to investigate biology we have as scientists, is the ability
to transfer genetic material in a controlled and deliberate manner between organisms. When …

This review deals with the latest advances in the study of embryonic stem cells (ESC) and
induced pluripotent stem cells (iPSC) from domesticated species, with a focus on pigs, cattle …

In pluripotent stem cells (PSCs), there are 2 types: naive and primed. Only the naive type
has the capacity for producing chimeric offspring. Mouse PSCs are naive, but human PSCs …

The pig is recognized as a valuable model in biomedical research in addition to its
agricultural importance. Here we describe a means for generating skeletal muscle efficiently …

Quercetin (QT) and taxifolin (TF) are structurally similar plant-derived flavonoids that have
antioxidant properties and act as free radical scavengers. The objective of this study was to …

Isoleucyl-tRNA synthetase (IARS) syndrome is a recessive disease of Japanese Black cattle
caused by a single nucleotide substitution. To repair the mutated IARS gene, we designed …

To date no authentic embryonic stem cell (ESC) line or germline-competent-induced
pluripotent stem cell (iPSC) line has been established for large animals. Despite this fact …

Efficient isolation of embryonic stem (ES) cells from pre-implantation porcine embryos has
remained a challenge. Here, we describe the derivation of porcine embryonic stem-like cells …

Current long term cryopreservation of cell stocks routinely requires the use of liquid nitrogen
(LN2), because commonly used cryopreservation media containing cell membrane …

The establishment of the pluripotent ICM during early mammalian development is
characterized by the differential expression of the transcription factors NANOG and …